The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Apr. 17, 2013
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Ping Tsui, Gaithersburg, MD (US);
Martin Borrok, II, Gaithersburg, MD (US);
William Dall'Acqua, Gaithersburg, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/10 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2887 (2013.01); A61K 39/39591 (2013.01); C07K 16/1027 (2013.01); C07K 16/18 (2013.01); C07K 16/2866 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/71 (2013.01); C07K 2317/94 (2013.01);
Abstract
Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.