The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Dec. 02, 2015
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 39/395 (2006.01); A61N 5/10 (2006.01); C07K 16/40 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 39/39558 (2013.01); A61N 5/10 (2013.01); C07K 16/30 (2013.01); C07K 16/3023 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 2039/507 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01);
Abstract
Methods of treating a subject having cancer exhibiting a resistance to a tyrosine kinase inhibitor (TKI) are provided. Accordingly, there is provided a method comprising administering to the subject a therapeutically effective amount of antibodies comprising an anti-EGFR antibody, an anti-HER2 antibody and an anti-HER3 antibody. Also provided are compositions and articles of manufacture for treating cancer resistance to a TKI. Also provided are methods of treating non-resistant tumors.