The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Feb. 13, 2015
Human androgen receptor dna-binding domain (dbd) compounds as therapeutics and methods for their use
The University of British Columbia, Vancouver, CA;
Artem Tcherkassov, Vancouver, CA;
Paul Rennie, Richmond, CA;
Fuqiang Ban, Markham, CA;
Huifang Li, Vancouver, CA;
Eric Joseph Jean LeBlanc, Vancouver, CA;
Kush Dalal, Vancouver, CA;
Anton V. Tverdokhlebov, Poltava, UA;
Sergiy Babiy, Kyiv, UA;
Evgeniia Bogomol, Kyiv, UA;
Kateryna Dunayenko, Kyiv, UA;
The University of British Columbia, Vancouver, CA;
Abstract
A compound having the structure of Formula I, wherein A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5- or 6-membered heteroaryl or heterocyclyl group and E is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl or heterocyclyl group. The compounds are used for the treatment of androgen modulated indications including cancer (prostate, breast, ovarian, endometrial or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, precocious puberty and age related macular degeneration. The use of the compounds for the manufacture of a medicament for modulating AR activity, a method of treatment using such compounds and a pharmaceutical composition and a commercial package comprising said compounds are also described.