The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Aug. 15, 2016
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Richard H. Ebright, New Brunswick, NJ (US);
David Degen, New Brunswick, NJ (US);
Yu Zhang, New Brunswick, NJ (US);
Yon Ebright, New Brunswick, NJ (US);
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
Abstract
The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I):X-α-Y  (I)wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and α is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.