The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
May. 27, 2016
Applicant:
Reber Genetics Co., Ltd., Taipei, TW;
Inventors:
Yu-Hsin Chien, Taipei, TW;
Meng-Ju Tsai, Taipei, TW;
Pao-Yen Lai, Taipei, TW;
Wei-I Chou, Taipei, TW;
Hsiu-Kang Chang, Taipei, TW;
Assignee:
REBER GENETICS CO., LTD., Taipei, TW;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C07K 14/005 (2006.01); C07K 14/21 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); C07K 14/005 (2013.01); C07K 14/21 (2013.01); A61K 2039/70 (2013.01); C07K 2319/04 (2013.01); C07K 2319/095 (2013.01); C07K 2319/55 (2013.01); C07K 2319/74 (2013.01); C12N 2750/10022 (2013.01); C12N 2750/10034 (2013.01); C12N 2770/10022 (2013.01); C12N 2770/10034 (2013.01);
Abstract
A fusion protein comprising an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, a translocation peptide, a fusion antigen, an endoplasmic reticulum retention sequence, and optionally a nuclear export signal is disclosed. The fusion antigen comprises a porcine reproductive and respiratory syndrome virus (PRRSV) ORF7 antigen, a PRRSV ORF1b antigen, a PRRSV ORF6 antigen, and a PRRSV ORF5 antigen. The fusion protein is useful for inducing antigen-specific cell-mediated and humoral responses.