The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Jun. 03, 2015
Institut Pasteur, Paris, FR;
Roland Brosch, Paris, FR;
Laleh Majlessi, Montigny-le-Bretonneux, FR;
Nadine Honore, Colombes, FR;
Matthias Groschel, Nuremberg, DE;
Fadel Sayes, Malakoff, FR;
Roxane Simeone, Paris, FR;
INSTITUT PASTEUR, Paris, FR;
Abstract
Recombinant strains ofbacille Calmette-Guerin (BCG) comprising a heterologous nucleic acid sequence of() are provided. In some embodiments the heterologous nucleic acid sequence ofcomprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the() proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to theproteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to theproteins MMAR5429, MMAR5430, MMAR5431, MMAR5432, MMAR5433, MMAR5434, MMAR5435, MMAR5436, MMAR5437, MMAR5438, MMAR5439, MMAR5440, MMAR5441, MMAR5442, MMAR5454, MMAR5456, MMAR5458, MMAR5459, MMAR5460, and MMAR5461. Pharmaceutical compositions, kits, methods of inducing an immune response againstin a subject, and methods of treating aninfection in a subject are also provided, among other things.