The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Nov. 03, 2014
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Thomas J. Tucker, North Wales, PA (US);
David M. Tellers, Lansdale, PA (US);
Boyoung Kim, Lansdale, PA (US);
Rob Burke, San Diego, CA (US);
Kathleen B. Calati, Hamilton, NJ (US);
Matthew G. Stanton, Marlton, NJ (US);
Rubina G. Parmar, Harleysville, PA (US);
Jeffrey G. Aaronson, Philadelphia, PA (US);
Weimin Wang, Churchville, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Disclosed herein is a method for inhibiting expression of a gene of a subject comprising administering (1) a composition comprising R-(L)-(G); wherein R is an oligonucleotide selected from the group consisting of DNA, RNA, siRNA, and microRNA; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; each of a and b is independently 0, 1, 2, 3 or 4; and (2) a composition comprising (P)-(L)-(G); wherein P is a peptide and each occurrence of P is independently selected from Table 2; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. Compositions in (1) and (2) can be co-administered or sequentially administered.