The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Jan. 29, 2015
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Chaitan Khosla, Palo Alto, CA (US);
Thomas DiRaimondo, Orinda, CA (US);
Cornelius Kloeck, Kaufbevren, DE;
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); C07D 413/14 (2006.01); A61K 38/44 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 38/44 (2013.01); C07D 413/14 (2013.01); C12Y 108/0401 (2013.01);
Abstract
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activity of TG2 associated with inflammatory disorders, which disorders may include, without limitation, sepsis, ischemic reperfusion injury, renal fibrosis, and the like.