The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Oct. 02, 2014
Applicant:
Universita Degli Studi Di Milano-bicocca, Milan, IT;
Inventors:
Massimo Masserini, Santa Margherita Ligure, IT;
Francesca Re, Busto Garolfo, IT;
Giulio Sancini, Gessate, IT;
Gianluigi Forloni, Rho, IT;
Mario Salmona, Milan, IT;
Assignee:
UNIVERSITA DEGLI STUDI DI MILANO-BICOCCA, Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/00 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1275 (2013.01); A61K 9/0019 (2013.01); A61K 9/1277 (2013.01); A61K 47/48246 (2013.01);
Abstract
New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.