The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2018

Filed:

Dec. 21, 2012
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Ramachandra Dasari, Shererville, IN (US);

Ishan Barman, Boston, MA (US);

Narahara Chari Dingari, Somerville, MA (US);

Jeon Woong Kang, Melrose, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01J 3/44 (2006.01); G01N 33/72 (2006.01); G01N 21/65 (2006.01); G01N 33/49 (2006.01);
U.S. Cl.
CPC ...
G01N 33/723 (2013.01); G01N 21/65 (2013.01); G01N 33/49 (2013.01); G01N 33/726 (2013.01); G01N 2440/38 (2013.01); G01N 2800/042 (2013.01);
Abstract

The present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data, which enable the accurate measurements and classification of glycated and unglycated analytes.


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