The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Nov. 25, 2014
Obschestvo S Ogranichennoy Otvetstvennostyu “gematologicheskaya Korporatsiya”, Moscow, RU;
Vladimir Nikolaevich Kolyadko, g. Zelenograd, RU;
Fazoil Inoyatovich Ataullakhanov, Moscow, RU;
Mikhail Aleksandrovich Panteleev, g. Mytishchi, RU;
Tatyana Alekseevna Vuymo, Moscow, RU;
Ruzanna Armenovna Ovsepyan, g. Puschino, RU;
Stepan Sergeevich Surov, g. Korolev, RU;
Vera Anatoljevna Korneeva, g. Himki, RU;
Abstract
The present invention relates to medicine, hematology, biotechnology and fundamental biological research; it can be used for diagnostic and research purposes when studying blood coagulation. One of the aspects of the invention is a polypeptide for selective inhibition of contact activation factor XIIa in a sample of blood or plasma, which comprises the sequence of infestin-4 MutB (SEQ ID NO: 1), where this sequence can have modifications outside the area of the inhibitory loop. Another aspect of the invention is a method of studying coagulation in the test sample, which includes bringing the sample into contact with this polypeptide, bringing a coagulation activator into contact with the sample, and measuring the coagulation parameters. Yet another aspect of the invention is a method of blood anticoagulation by this polypeptide for collection purposes and in order to increase the storage time of the sample.