The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
May. 28, 2014
Applicants:
Cellectis, Paris, FR;
Precision Genome Engineering, Inc., Tumwater, WA (US);
Inventors:
Jordan Jarjour, Seattle, WA (US);
Alexander Astrakhan, Seattle, WA (US);
Assignees:
CELLECTIS, Paris, FR;
PRECISION GENOME ENGINEERING, INC., Tumwater, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 9/22 (2006.01); A61K 35/17 (2015.01); A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); A61K 35/17 (2013.01); A61K 38/465 (2013.01); C12N 9/22 (2013.01); C12Y 301/00 (2013.01);
Abstract
Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided.