The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Mar. 12, 2014
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Katie Streicher, Gaithersburg, MD (US);
Jonathan Jacobs, Gaithersburg, MD (US);
Robert W. Georgantas, III, Gaithersburg, MD (US);
Lydia Greenlees, Gaithersburg, MD (US);
Koustubh Ranade, Gaithersburg, MD (US);
Michael Bowen, Gaithersburg, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12P 21/02 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/42 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C07K 14/705 (2013.01); C07K 16/00 (2013.01); C07K 16/4208 (2013.01); C12N 9/00 (2013.01); C12P 21/02 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/40 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C12N 2310/113 (2013.01); C12N 2330/50 (2013.01); C12N 2799/027 (2013.01); C12Q 2600/178 (2013.01);
Abstract
Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microRNA activity level. In one embodiment, a microRNA activity level is increased. In another embodiment, a microRNA activity level is decreased. In a more particular embodiment, the mammalian cells have a reduced miRNA-let-7a activity level.