The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Nov. 19, 2013
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Frederic Zecri, Brookline, MA (US);
Kayo Yasoshima, Cambridge, MA (US);
Philipp Grosche, Inzlingen, DE;
Jun Yuan, Boston, MA (US);
Hongjuan Zhao, Lexington, MA (US);
Assignee:
NOVARTIS AG, Basel, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 14/765 (2006.01); C07K 14/47 (2006.01); A61K 45/06 (2006.01); A61K 38/38 (2006.01);
U.S. Cl.
CPC ...
C07K 14/765 (2013.01); A61K 38/385 (2013.01); A61K 45/06 (2013.01); C07K 14/47 (2013.01);
Abstract
The invention relates to novel compositions comprising modified apelin-13 peptide sequences designed to treat cardiovascular disease in subjects to whom they are administered, and which exhibit greater resistance to degradation, and equivalent or greater bioactivity than their wild type counterparts. The invention also relates to methods of making said compositions and using said compositions as pharmaceutically active agents to treat cardiovascular disease.