The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Mar. 19, 2015
Applicants:
Amydis Diagnostics, Inc., Beverly Hills, CA (US);
The Regents of the University of California, Oakland, CA (US);
Inventors:
Jerry Yang, La Jolla, CA (US);
Emmanuel A. Theodorakis, San Diego, CA (US);
Stella Sarraf, Beverly Hills, CA (US);
Assignees:
The Regents Of The University Of California, Oakland, CA (US);
Amydis, Inc., San Diego, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 295/155 (2006.01); C07D 213/85 (2006.01); C07H 19/056 (2006.01); C07D 409/14 (2006.01); C07D 241/04 (2006.01); C07D 295/04 (2006.01); C07D 307/52 (2006.01); C07D 401/14 (2006.01); C07C 311/35 (2006.01); C07C 255/59 (2006.01); C07D 413/12 (2006.01); C07D 405/04 (2006.01); C07D 211/06 (2006.01); C07D 405/10 (2006.01); C07D 213/57 (2006.01); C07D 409/04 (2006.01); C07D 407/10 (2006.01); C07C 255/58 (2006.01); C07D 265/30 (2006.01); C07C 255/42 (2006.01); C07D 413/10 (2006.01); C07D 333/22 (2006.01); C07D 401/04 (2006.01); C07D 409/10 (2006.01);
U.S. Cl.
CPC ...
C07D 295/155 (2013.01); C07C 255/42 (2013.01); C07C 255/58 (2013.01); C07C 255/59 (2013.01); C07C 311/35 (2013.01); C07D 211/06 (2013.01); C07D 213/57 (2013.01); C07D 213/85 (2013.01); C07D 241/04 (2013.01); C07D 265/30 (2013.01); C07D 295/04 (2013.01); C07D 307/52 (2013.01); C07D 333/22 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/10 (2013.01); C07D 407/10 (2013.01); C07D 409/04 (2013.01); C07D 409/10 (2013.01); C07D 409/14 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07H 19/056 (2013.01);
Abstract
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.