The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2018

Filed:

Sep. 06, 2017
Applicant:

Theravance Biopharma R&d Ip, Llc, South San Francisco, CA (US);

Inventors:

Melissa Fleury, Brisbane, CA (US);

Anne-Marie Beausoleil, Redwood City, CA (US);

Adam D. Hughes, Half Moon Bay, CA (US);

Daniel D. Long, San Francisco, CA (US);

Donna A. A. Wilton, San Francisco, CA (US);

Assignee:

THERAVANCE BIOPHARMA R&D IP, LLC, South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 295/24 (2006.01); C07D 317/10 (2006.01); C07D 263/38 (2006.01); C07D 271/07 (2006.01); C07D 249/10 (2006.01); C07D 205/04 (2006.01); C07D 267/02 (2006.01); C07D 249/04 (2006.01); C07D 261/18 (2006.01); C07D 263/34 (2006.01); C07D 239/28 (2006.01); C07D 231/14 (2006.01); C07D 275/03 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01); C07D 213/81 (2006.01); C07D 231/20 (2006.01);
U.S. Cl.
CPC ...
C07D 249/04 (2013.01); C07D 213/81 (2013.01); C07D 231/14 (2013.01); C07D 231/20 (2013.01); C07D 239/28 (2013.01); C07D 249/10 (2013.01); C07D 261/18 (2013.01); C07D 263/34 (2013.01); C07D 263/38 (2013.01); C07D 271/07 (2013.01); C07D 275/03 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01);
Abstract

In one aspect, the invention relates to compounds having the formula I: where R-Rare as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.


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