The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2018

Filed:

Apr. 04, 2014
Applicants:

North Carolina Central University, Durham, NC (US);

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Jonathan Z. Sexton, Raleigh, NC (US);

Jay E. Brenman, Chapel Hill, NC (US);

David L. Musso, Raleigh, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 235/64 (2006.01); A61K 45/06 (2006.01); C07C 255/60 (2006.01); C07C 233/66 (2006.01); C07C 233/81 (2006.01); C07C 235/68 (2006.01); C07D 213/75 (2006.01); C07D 213/82 (2006.01); C07D 249/08 (2006.01); C07D 257/04 (2006.01); C07D 271/06 (2006.01); C07D 295/155 (2006.01); A61K 31/167 (2006.01); A61K 31/196 (2006.01); A61K 31/245 (2006.01); A61K 31/277 (2006.01); A61K 31/40 (2006.01); A61K 31/44 (2006.01); A61K 31/5375 (2006.01); C07C 45/46 (2006.01); C07C 67/39 (2006.01); C07C 231/02 (2006.01); C07C 253/30 (2006.01); C07D 207/34 (2006.01);
U.S. Cl.
CPC ...
C07C 235/64 (2013.01); A61K 31/167 (2013.01); A61K 31/196 (2013.01); A61K 31/245 (2013.01); A61K 31/277 (2013.01); A61K 31/40 (2013.01); A61K 31/44 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07C 45/46 (2013.01); C07C 67/39 (2013.01); C07C 231/02 (2013.01); C07C 233/66 (2013.01); C07C 233/81 (2013.01); C07C 235/68 (2013.01); C07C 253/30 (2013.01); C07C 255/60 (2013.01); C07D 207/34 (2013.01); C07D 213/75 (2013.01); C07D 213/82 (2013.01); C07D 249/08 (2013.01); C07D 257/04 (2013.01); C07D 271/06 (2013.01); C07D 295/155 (2013.01); C07C 2601/14 (2017.05);
Abstract

The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.


Find Patent Forward Citations

Loading…