The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Jul. 01, 2014
Applicant:
University of Georgia Research Foundation, Inc., Athens, GA (US);
Inventors:
Shanta Dhar, Athens, GA (US);
Rakesh Pathak, Athens, GA (US);
Assignee:
University of Georgia Research Foundation Inc., Athens, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/54 (2006.01); A61K 47/48 (2006.01); A61K 47/59 (2017.01); A61K 47/54 (2017.01); A61K 45/06 (2006.01); A61K 31/663 (2006.01); A61K 31/675 (2006.01); C07F 9/6518 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48023 (2013.01); A61K 9/5146 (2013.01); A61K 9/5184 (2013.01); A61K 31/663 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); A61K 47/482 (2013.01); A61K 47/54 (2017.08); A61K 47/593 (2017.08); C07F 9/5442 (2013.01); C07F 9/65181 (2013.01);
Abstract
Described is a targeted molecular scaffold for construction of a metabolic inhibitor loaded with cancer-cell specific activity and anti-tumor immunity. Incorporation of a mitochondria targeting moiety such as triphenylphosphonium cation through a biodegradable linker in allowed for mitochondria targeting of certain metabolic inhibitors like dichloroacetic acid (DCA).