The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Jul. 01, 2016
Applicant:
Agency for Science, Technology and Research, Singapore, SG;
Inventors:
Antonio Bertoletti, Singapore, SG;
Adam Gehring, Singapore, SG;
Assignee:
Agency for Science, Technology and Research, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 39/29 (2006.01); C12Q 1/70 (2006.01); C07K 14/705 (2006.01); A61K 45/06 (2006.01); C12Q 1/6886 (2018.01); G01N 33/569 (2006.01); G01N 33/574 (2006.01); A61K 47/64 (2017.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/292 (2013.01); A61K 45/06 (2013.01); A61K 47/6425 (2017.08); C07K 14/705 (2013.01); C12Q 1/6886 (2013.01); C12Q 1/706 (2013.01); G01N 33/56983 (2013.01); G01N 33/57438 (2013.01); A61K 38/00 (2013.01); A61K 2039/5158 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/02 (2013.01); Y10T 436/143333 (2015.01);
Abstract
There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for producing them. In particular, there is provided polynucleotides, constructs and vectors encoding at least one HBV epitope-reactive exogenous T cell receptor for use in the treatment of Hepatitis B Virus (HBV) and Hepatocellular Carcinoma (HCC). The invention further provides kits and methods of detection of HBV and HCC.