The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Jan. 30, 2017
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Xiaodong Wang, Chapel Hill, NC (US);
Weihe Zhang, Vestavia, AL (US);
Stephen Frye, Chapel Hill, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A01N 43/90 (2006.01); A61K 31/635 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/529 (2006.01);
U.S. Cl.
CPC ...
A61K 31/635 (2013.01); A61K 31/519 (2013.01); A61K 31/529 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01);
Abstract
Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK−/− tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.