The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 26, 2018

Filed:

May. 23, 2016
Applicants:

Institut Quimic DE Sarria, Barcelona, ES;

Universitad Politecnica DE Valencia, Valencia, ES;

Fundacio Germans Trias Pujol, Badalona, ES;

Association Cardio-monde, Paris, FR;

Inventors:

Juan Carlos Chachques, Paris, FR;

Antonio Bayes Genis, Principal, ES;

Manuel Monleon Pradas, Valencia, ES;

Carlos Eduardo Semino, Barcelona, ES;

Philippe Jenny, Pessac, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/24 (2006.01); A61L 27/26 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61F 2/00 (2006.01); A61L 27/58 (2006.01); C12N 5/077 (2010.01); C12N 5/0775 (2010.01); A61L 27/16 (2006.01); A61L 27/24 (2006.01);
U.S. Cl.
CPC ...
A61F 2/2481 (2013.01); A61F 2/0077 (2013.01); A61F 2/24 (2013.01); A61L 27/16 (2013.01); A61L 27/24 (2013.01); A61L 27/26 (2013.01); A61L 27/3834 (2013.01); A61L 27/3839 (2013.01); A61L 27/3873 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); C12N 5/0657 (2013.01); C12N 5/0663 (2013.01); C12N 5/0667 (2013.01); A61F 2002/0081 (2013.01); A61F 2210/0004 (2013.01); A61F 2210/0057 (2013.01); A61F 2220/0008 (2013.01); A61F 2220/0016 (2013.01); A61F 2240/001 (2013.01); A61L 2300/252 (2013.01); A61L 2300/44 (2013.01); A61L 2300/442 (2013.01); A61L 2300/602 (2013.01); A61L 2400/12 (2013.01); A61L 2430/20 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01);
Abstract

Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restoration of the heart conical shape. Cardiac wrapping by ventricular support bioprostheses of the present invention, having reinforcement bands spatially distributed as helicoids, recovers the sequential contraction of the myocardium resulting in the successive shortening and lengthening of the ventricles, therefore improving the ejection (systolic function) and suction of blood (diastolic function).


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