The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Jan. 24, 2011
David Alsop, Newton, MA (US);
Rachel Scheidegger, Boston, MA (US);
David Alsop, Newton, MA (US);
Rachel Scheidegger, Boston, MA (US);
Beth Israel Deaconess Medical Center, Boston, MA (US);
Abstract
A method for chemical exchange saturation transfer ('CEST') imaging that is more insensitive to off-resonance and magnetization transfer effects than other CEST methods is provided. Sn general, three different images are obtained: one obtained with radio frequency ('RF') saturation about a labeling frequency, one obtained with RF saturation about a reference frequency, and one obtained with RF saturation about both the labeling and reference frequencies. This method, termed saturation with frequency alternating radiofrequency irradiation (“SAFARI”), is also very robust to magnetic field inhomogeneities. The three images, referred to as a labeled image, reference image, and dual frequency image, are selectively combined to produce an image of the subject in which CEST contrast is present, but errors arising from off-resonance and magnetization transfer effects are substantially suppressed.