The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Apr. 06, 2015
Applicant:

Hirosaki University, Hirosaki-shi, Aomori, JP;

Inventors:

Katsuya Yamada, Hirosaki, JP;

Ayako Sasaki, Hirosaki, JP;

Tadashi Teshima, Ibaraki, JP;

Toshihiro Yamamoto, Ibaraki, JP;

Yuji Otsuka, Ibaraki, JP;

Assignee:

HIROSAKI UNIVERSITY, Hirosaki-Shi, Aomori, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/54 (2006.01); G01N 33/66 (2006.01); C07H 17/075 (2006.01); C07H 19/04 (2006.01); A61K 49/00 (2006.01); C07H 17/02 (2006.01); G01N 33/574 (2006.01); G01N 33/58 (2006.01); A61K 51/04 (2006.01);
U.S. Cl.
CPC ...
G01N 33/66 (2013.01); A61K 49/0002 (2013.01); A61K 49/0021 (2013.01); A61K 49/0039 (2013.01); A61K 49/0052 (2013.01); A61K 51/0491 (2013.01); C07H 17/02 (2013.01); C07H 17/075 (2013.01); C07H 19/04 (2013.01); G01N 33/574 (2013.01); G01N 33/582 (2013.01);
Abstract

Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.


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