The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Aug. 28, 2015
Applicant:

Dh Technologies Development Pte Ltd., Singapore, SG;

Inventors:

John L Campbell, Milton, CA;

Yves LeBlanc, Newmarket, CA;

Chang Liu, Richmond Hill, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/14 (2006.01); C07K 1/00 (2006.01); B01D 59/44 (2006.01); B01D 15/38 (2006.01); B01D 15/36 (2006.01); C12Q 1/68 (2018.01); G01N 33/53 (2006.01); H01J 49/26 (2006.01); G01N 27/62 (2006.01); H01J 49/04 (2006.01); H01J 49/10 (2006.01);
U.S. Cl.
CPC ...
G01N 27/624 (2013.01); H01J 49/04 (2013.01); H01J 49/10 (2013.01);
Abstract

Methods and systems for separating and/or quantifying peptides using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of one or more peptides, for example, peptides that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), by complexing the peptides with a metal cation (e.g., Ca2+) prior to DMS. In some aspects, the present teachings can prevent proton stripping from ionized peptides that can occur in DMS to prevent unintended and/or undesirable alterations to the peptide's charge state distribution.


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