The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Sep. 06, 2002
Applicant:

Don Straus, Cambridge, MA (US);

Inventor:

Don Straus, Cambridge, MA (US);

Assignee:

First Light Biosciences, Inc., Bedford, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/00 (2006.01); C12Q 1/06 (2006.01); B82Y 20/00 (2011.01); C12Q 1/04 (2006.01); C12Q 1/18 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); G01N 33/58 (2006.01); G01N 15/14 (2006.01); G01N 21/64 (2006.01); B82Y 5/00 (2011.01); B82Y 10/00 (2011.01);
U.S. Cl.
CPC ...
C12Q 1/06 (2013.01); B82Y 20/00 (2013.01); C12Q 1/04 (2013.01); C12Q 1/18 (2013.01); G01N 15/1429 (2013.01); G01N 21/6428 (2013.01); G01N 33/5005 (2013.01); G01N 33/5008 (2013.01); G01N 33/56916 (2013.01); G01N 33/56938 (2013.01); G01N 33/56966 (2013.01); G01N 33/56983 (2013.01); G01N 33/58 (2013.01); G01N 33/582 (2013.01); B82Y 5/00 (2013.01); B82Y 10/00 (2013.01); G01N 15/1475 (2013.01); G01N 2015/1488 (2013.01); G01N 2021/6439 (2013.01); G01N 2021/6471 (2013.01); G01N 2333/195 (2013.01); G01N 2333/245 (2013.01); G01N 2333/31 (2013.01); G01N 2333/32 (2013.01); G01N 2333/33 (2013.01);
Abstract

The invention features methods for rapidly and sensitively identifying molecular targets in medical, industrial, and environmental samples. The invention labels target molecules and then images them using large area imaging. Diagnostic tests based on the invention can be rapid, ultrasensitive, quantitative, multiplexed, and automated. A broad range of infectious agents (e.g., bacteria, viruses, fungi, and parasites) and molecules (e.g., proteins, DNA, RNA, hormones, and drugs) can be detected by the methods. The invention enables rapid, ultra-sensitive, cost-effective, and portable assays. The ability of the invention to detect low levels of target molecules rapidly and cost-effectively results from the combination of high intensity labeling, formats that facilitate rapid reaction kinetics, and large area imaging based using either instrumentation made from off-the-shelf commercial components or no instrumentation at all.


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