The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Apr. 19, 2016
Applicant:

Genomatica, Inc., San Diego, CA (US);

Inventors:

Anthony P. Burgard, Bellefonte, PA (US);

Robin E. Osterhout, San Diego, CA (US);

Stephen J. Van Dien, Encinitas, CA (US);

Cara Ann Tracewell, Solana Beach, CA (US);

Priti Pharkya, San Diego, CA (US);

Stefan Andrae, San Diego, CA (US);

Assignee:

Genomatica, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/52 (2006.01); C12P 7/42 (2006.01); C08F 120/06 (2006.01); C08G 63/664 (2006.01); C12N 15/63 (2006.01); C12P 7/24 (2006.01); C12P 7/40 (2006.01); C12N 9/04 (2006.01); C12N 9/06 (2006.01); C12N 9/10 (2006.01); C12P 7/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/52 (2013.01); C08F 120/06 (2013.01); C08G 63/664 (2013.01); C12N 9/0006 (2013.01); C12N 9/0028 (2013.01); C12N 9/1007 (2013.01); C12N 15/63 (2013.01); C12P 7/24 (2013.01); C12P 7/40 (2013.01); C12P 7/42 (2013.01); C12P 7/62 (2013.01); C12Y 101/01244 (2013.01); C12Y 105/0102 (2013.01); C12Y 201/0109 (2013.01);
Abstract

Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.


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