The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
Jun. 15, 2015
Applicant:
Genmab A/s, Copenhagen V, DK;
Inventors:
Aran Frank Labrijn, Amsterdam, NL;
Stefan Loverix, Ternat, BE;
Paul Parren, Odijk, NL;
Jan Van De Winkel, Zeist, NL;
Janine Schuurman, Diemen, NL;
Ignace Lasters, Antwerp, BE;
Assignee:
Genmab A/S, Copenhagen V, DK;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/00 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 51/10 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 39/3955 (2013.01); A61K 47/48561 (2013.01); A61K 51/103 (2013.01); C07K 16/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.