The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
May. 09, 2014
The United States of America, As Represented BY the Secretary, Depart of Health and Human Services, Bethesda, MD (US);
Instituto Nacional DE Tecnologia Agropecuaria, Ciudad Autonoma de Buenos Aires, AR;
Karin Bok, Bethesda, MD (US);
Lorena Laura Garaicoechea, Buenos Aires, AR;
Viviana Parreno, Buenos Aires, AR;
Andrea Pamela Aguilar, Buenos Aires, AR;
Marina Bok, Buenos Aires, AR;
Lisbeth Kim Green, Olney, MD (US);
Stanislav Vladimirovich Sosnovtsev, North Potomac, MD (US);
THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human Services, Washington, DC (US);
INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIA, Buenos Aires, AR;
Abstract
Isolated VH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.