The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
Nov. 01, 2012
Applicant:
Seattle Genetics, Inc., Bothell, WA (US);
Inventors:
Svetlana O. Doronina, Snohomish, WA (US);
Toni Beth Kline, Seattle, WA (US);
Assignee:
Seattle Genetics, Inc., Bothell, WA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 5/02 (2006.01); C07K 7/02 (2006.01); C07K 16/28 (2006.01); C07K 5/10 (2006.01); C07K 7/06 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); A61K 47/65 (2017.08); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08); C07K 5/0205 (2013.01); C07K 5/10 (2013.01); C07K 7/02 (2013.01); C07K 7/06 (2013.01); C07K 16/2878 (2013.01); A61K 38/00 (2013.01);
Abstract
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.