The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2018

Filed:

Jun. 05, 2017
Applicant:

Meiji Seika Pharma Co., Ltd., Chuo-ku, Tokyo, JP;

Inventors:

Takao Abe, Kanagawa, JP;

Takeshi Furuuchi, Kanagawa, JP;

Yoshiaki Sakamaki, Kanagawa, JP;

Nakako Mitsuhashi, Kanagawa, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/08 (2006.01); C07D 401/12 (2006.01); C07D 211/60 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); C07D 211/60 (2013.01); C07D 401/12 (2013.01); Y02P 20/55 (2015.11);
Abstract

A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula with a compound selected from the group consisting of 1-hydroxypyrrolidine-2,5-dione, 2-hydroxy-3a,4,7,7a-tetrahydro-1H-isoindol-1,3(2H)-dione, 2-hydroxyhexahydro-1H-isoindol-1,3(2H)-dione and 4-hydroxy-4-azatricyclo[5.2.1.0]dec-8-ene-3,5-dione, carrying out a carbonylation to obtain a compound of the following formula removing the NH protecting group P and treating the resultant compound with a base to produce a compound represented by the following formula wherein OBn is benzyloxy and Ris hydrogen, ClCO— or ClCOCO—.


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