The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
May. 26, 2015
Asymchem Laboratories (Tianjin) Co., Ltd, TEDA Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd, TEDA Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd, TEDA Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd, Liaoning, CN;
Jilin Asymchem Laboratories Co., Ltd, Jilin, CN;
Hao Hong, TEDA Tianjin, CN;
Gage James, TEDA Tianjin, CN;
Jiuyuan Li, TEDA Tianjin, CN;
Changfeng Li, TEDA Tianjin, CN;
Gaochao Huang, TEDA Tianjin, CN;
ASYMCHEM LABORATORIES (TIANJIN) CO., LTD, Teda Tianjin, CN;
TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD, Tianjin, CN;
JILIN ASYMCHEM LABORATORIES CO., LTD, Jilin, CN;
ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD, Teda Tianjin, CN;
ASYMCHEM LABORATORIES (FUXIN) CO., LTD, Liaoning, CN;
Abstract
A method for preparing nilotinib includes the following steps: performing an aminocarbonylation reaction on a compound A and 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline to obtain an amination product; and performing deprotection treatment of an R group on the amination product to obtain the nilotinib, wherein the compound A has a structure shown in formula I, and in formula I, an R group is selected from benzyl, —COCF, —CHO or —COR', where an R′ group is C˜Calkyl, C˜Calkoxy ethyl or C˜Caralkyl.