Cytrx Corporation

Éva Udvardy

László Ürögdi

Gábor Balogh

Ede Márványos

Ibolya Horváth

Péter Literáti Nagy

Mária Kürthy

Zsolt Török

László Vígh

Beatrix Farkas

Attila Glatz

György Dormán

Andrea Jednákovits

Katalin Bíró

László Korányi

Dénes Medzihradszky

Bea Mézes

Eszter Kovács

László Jaszlits

Mihály Barabás

Erzsébet Hegedüs

Jenö Szilbereky

Ernö Duda

Jenó Szilbereky

Ernó Duda

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof

Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof

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Budapest, Hungary

Éva Udvardy