Given Imaging Ltd.

Zvika Gilad

Gavriel Joseph Iddan

Semion Khait

Amit Pascal

Arkady Glukhovsky

Mordechai Yehuda Frisch

Chen Mann

Elisha Rabinovitz

Daniel Gat

Gavriel David Meron

Shlomo Lewkowicz

Jerome Avron

Daphna Levy

Yehudit Kraizer

Nathan Rubin

David Leuw

Haim Bezdin

Yaniv Birnboim

Eli Horn

Ori J Braun

Tal Davidson

Osnat Sella-Tavor

Raphael Rabinovitz

Alex Blijevsky

Reuven Schreiber

Daniel Shmuel Afik

Howard D Manten

Vitaly Fastovsky

Yosef Druyan

Vitaly Roytenburd

Yossi Druyan

In-vivo devices, systems and methods for the detection of blood within in-vivo bodily fluids. The methods include irradiating in-vivo fluids passing through a gap in a housing of an in-vivo device introduced to the GI tract of a subject with a plurality of illumination sources positioned on a first side of a gap; detecting with at least one light detector positioned on the opposite side of the gap and facing the illumination sources, light irradiated by the illumination sources; transmitting a plurality of values representing the light detected over time; converting these values to blood concentration values over time, and comparing the blood concentration values to a predetermined threshold value. Based on the comparison, the method includes determining the type of bleeding profile, such that if a plurality of blood concentration values measured consecutively is above the threshold value, the bleeding profile indicates bleeding.

Device, system and method for in-vivo detection of bleeding in the gastrointestinal tract

An in vivo capsule has a cauterization element that may be deployed by physician while in vivo for cauterizing a lesion, such as bleeding. Energy is transferred from outside of the patient's body to the capsule and specifically to the ablating element, such as via a resonance circuit. Accordingly, it is the object of the present invention to provide a method and apparatus for precisely cauterizing or ablating tissue in-vivo. Embodiments of the invention may provide an in-vivo device having a cauterization or ablation element incorporated therein and a system and method for controlled navigation of the in-vivo cauterization device through a body lumen.

Method and apparatus for in-vivo cauterization of lesions and malignancies

The invention provides a device for in-vivo imaging, for example, using an in-vivo imaging device including an imager a lens and an illumination source, all positioned behind a single viewing window. The in-vivo imaging device may include an element to block light from reaching a point of reflection on the inner surface of the viewing window, thereby preventing the light from being received by the imager.

In-vivo imaging device with backscatter blocking

A device and method for viewing a body lumen are provided. An assembly of a capsule endoscope and an endoscope is inserted into a body lumen. The capsule endoscope is positioned within the body lumen at a predetermined distance from the endoscope, and images are obtained from opposite sides of a desired location in the body lumen. In vivo procedures may be performed, while images of the procedure are obtained from opposite sides of the procedure location.

Device and method for viewing a body lumen

In-vivo optical imaging device with backscatter blocking

In-vivo medical devices, systems and methods of operating such devices include a permanent magnetic assembly interacting with external magnetic fields for magnetically maneuvering said device to a desired location along a patient's GI tract, and anchoring said devices to the desired location for a period of time. The in-vivo medical device includes illumination sources, an optical system, and an image sensor for imaging the GI tract and thus assisting in locating the desired location. Some in-vivo medical devices include a concave window, which enables better imaging of small areas along the tissue. Furthermore, in-vivo devices with a concave window enable carrying operating tools without damaging the tissue of the GI tract, since prior to operation, the tools protrude from the concave window but remain behind the ends of the edges of the concave window.

System and apparatus for anchoring and operation of in-vivo medical devices

A sleeve for simple assembly of in-vivo devices, such as endoscopy capsules, is provided. The sleeve comprises grippers and leaf springs at either end to hold the rigid portions of a rigid-flex PCB (printed circuit board) in a folded configuration before the PCB is inserted into an in-vivo device's housing. A method of assembly of the rigid-flex PCB into the sleeve is provided.

Device and method for assembling in vivo sensing devices

A flexible circuit board for being inserted into an in-vivo imaging device is provided. The flexible circuit board may include a plurality of flexible installation units connected to one another through flexible connection units. The flexible installation units may be capable of having electrical components disposed thereon at a size suitable for being included in an in-vivo imaging device which may be inserted into a body lumen, e.g., a capsule endoscope. An in-vivo imaging device which may enclose such a full-flexible circuit board is also provided.

In vivo sensing device with a flexible circuit board

A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.

Device, system and method for detection of bleeding

A system and method for indicating transferability of a non-dissolvable target in-vivo device through the GI tract are described. The in vivo system includes a dissolvable in-vivo device which has two operational phases; an initial phase in which the device is of initial dimensions and a final phase in which the device is of final dimensions. In the initial phase the device can pass freely through a normally configured body lumen whereas it may not be able to pass freely through an abnormally configured lumen. In the final phase the device can pass freely through a body lumen even if it is abnormally configured.

Device and method for examining a body lumen

An assembly for aligning an optical system over an image sensor is described. The assembly may include a lens structure positioned over an image sensor and a lens holder positioned over the lens structure and secured onto a substrate. The lens structure may incorporate an optical section and a structural section extending from the optical section and may rest directly on an image sensor with one or more stoppers that may serve to elevate the optical system with respect to the image sensor at a distance corresponding to a near optimal focal length distance. A lip also included in the structural section of the lens structure may abut two or more opposing sides to secure the lens structure over the image sensor in a centered position with respect to the image sensor.

Assembly and method for aligning an optical system

An in-vivo device, system and a method for imaging a body lumen, typically liquid filled body lumen. The in-vivo device may have a specific gravity of about 1 or a volume to weight ratio that enables it to float. The in-vivo device may include an optical system for viewing through a body lumen liquid and another optical system for viewing through a non liquid medium. The in-vivo device may be moved through the body lumen by the liquid movement in that lumen.

Device, system and method for in-vivo imaging of a body lumen

A wearable antenna assembly includes a posterior antenna assembly and an anterior antenna assembly. The posterior antenna assembly may include a posterior base that includes a lateral portion having a lateral line, and one or two protrusions that continue from the lateral portion and extend away from it, and one or more antenna elements that are formed in the respective protrusion. The protrusions may be configured such that each antenna element lies on the buttocks and is situated adjacent to, or in front of, a greater sciatic notch of the pelvis. The anterior antenna assembly may include an anterior lateral base having a lateral line, and n antenna elements that are formed in the anterior lateral base along the lateral line. The anterior lateral base may be configured such that, when the belt is worn, the n antenna elements are situated adjacent to, or in front of, the abdomen. The orientations of the antenna elements may be optimized to maximize reception of signals originating from a swallowed in-vivo device.

Wearable antenna assembly for an in-vivo device

An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.

Device, system and method for examining a body lumen

A method of assembling an in-vivo imaging device with a flexible circuit board. The flexible circuit board may include a plurality of flexible installation units connected to one another through flexible connection units. The flexible installation units may be capable of having electrical components disposed thereon at a size suitable for being included in an in-vivo imaging device which may be inserted into a body lumen, e.g., a capsule endoscope.

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Haifa, Israel

Zvika Gilad