Alpha Omega Engineering Ltd.

Alpha Omega Neuro Technologies Ltd.

Zvi Israel

Hagai Bergman

Steven E Scott

Adi Balan

Paul McSherry

Imad Younis

Benjamin Matter

Omer Naor

Dan Valsky

Jubran Elfar

John Rizik

Renana Eitan

Majd Sleem

Odeya Marmor

Adam Zaidel

Oren A Gargir

Majid Mechael

A system for differential recording connectable to an electrical lead with at least two electrodes, including:

Brain navigation methods and device

A brain navigation device, comprising a lead with an elongated lead body, at least one macro-electrode contact positioned on an outer surface on the lead, wherein the at least one macro-electrode contact is located at the distal part of the lead, and wherein the at least one macro-electrode contact is configured to be used during lead navigation.

Brain navigation lead

The disclosure relates to an automatic brain-probe guidance systems. Specifically, the disclosure is directed to a real-time method and system for guiding a probe to the dorsolateral oscillatory region of the subthalamic nucleus in the brain of a subject in need thereof using factored Partially Observable Markov Decision Process (POMDP) via Hidden Markov Model (HMM) represented as a dynamic Bayesian Network (DBN).

Automatic brain probe guidance system

A real-time method and system to accurately demarcate sub-territories of the subthalamic nucleus area in the brain during surgery, based on microelectrode recordings and a Hidden Markov Model. Root mean square and power spectral density of the microelectrode recordings are used to train and test Hidden Markov Model in identifying the dorsolateral oscillatory region and non-oscillatory sub-territories within the subthalamic nucleus. After the dorsolateral oscillatory region in the subthalamic nucleus is mapped, the microelectrodes are removed, and a macroelectrode is inserted in the mapped dorsolateral oscillatory region for producing deep brain simulation for treatment of Parkinson's disease.

Real-time methods and systems for mapping a target region in the brain during surgery

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Jerusalem, Israel

Zvi Israel