Teva Pharmaceutical Industries Limited

Sicor Inc.

Zvi Harel

Marco Villa

Revital Lifshitz-Liron

Vinod Kumar Kansal

Alessandro Pontiroli

Igor Rukhman

Nicola Diulgheroff

Maytal Piran

Jonathan Busolli

Moran Pirkes

Peter Lindsay MacDonald

Pierluigi Rossetto

Csilla Nemethne Racz

Rami Lidor-Hadas

Suhail Ahmad

Ettore Bigatti

Eti Kovalevski

Eti Kovalevski-Liron

Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.

Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid

Crystalline forms of Varenicline Tosylate: are provided, along with processes for preparing those crystalline forms of Varenicline Tosylate, and processes for obtaining high purity Varenicline base using Varenicline Tosylate.

Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate

The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

Process for the preparation of letrozole

Provided is a process for preparing valsartan and precursors thereof.

Process for the preparation of valsartan

Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phoshorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, a inert support or ortho-phosphoric acid codiluent is advantageously included.

Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons

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Kfar Saba, Israel

Zvi Harel