Sarnoff Corporation

Izun Pharmaceuticals Corporation

Lifecodes Corporation

Rosedale Medical, Inc.

Alfa Wassermann, Inc.

Intuity Medical, Inc.

Zvi Gerald Loewy

William Zev Levine

Aron Jay Saffer

Bawa Singh

Christopher C Gregory

Peter John Zanzucchi

William Ronald Roach

John Gregory Aceti

Richard Morgan Moroney, Iii

Zygmunt Marian Andrevski

Rajan Kumar

Howard J Baum

Peter David Southgate

Nancy Y Ip

Ivan Balazs

John Neuweiler

Vivian Ruvolo

Ravinder C Mehra

Susan L Leary

Ingrid L Van De Stadt

Aron J Saffer

Richard Morgan Moroney

Christopher Carter Gregory

Richard Morgan Iii Moroney

Zygmunt M Andrevski

Provided, among other things, is a method of treating or ameliorating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a rinse comprising: an effective amount of appropriate composition of herbal bioactive comprising active(s) of one or more ofor; an antimicrobially effective amount of a quaternary ammonium surfactant; and optionally a polymer or mixture of polymers effective to coat said tissue and entrap said extract(s).

Mucosal formulation

Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.

Anti-inflammatory dissolvable film

A method of treating or ameliorating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a rinse comprising: an effective amount of appropriate composition of herbal bioactive comprising active(s) of one or more ofor; an antimicrobially effective amount of a quaternary ammonium surfactant; and optionally a polymer or mixture of polymers effective to coat said tissue and entrap said extract(s).

Oral rinse

Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.

Analyte monitor

The invention relates to a pipette sampling system that allows for automated sampling from the contents of a capped sample tube. More specifically, the invention relates to a pipette tip, having a piercing tip attached thereto, for removal of aliquots of samples from capped sample tubes comprising said samples.

Pipette sampling system

Provided is a liquid handling device comprising: a cylindrical actuator cavity in a substrate, the actuator cavity intersected by two or more actuator channels; one or more chambers with an access channel adapted to connect to a separate one of actuator channels; and a actuator comprising (a) a cylindrical body having a cylinder axis and having therein a liquid-handling compartment with, arrayed along the cylinder axis, a first end and a second end, the liquid-handling compartment being closed at the second end, (b) a dispensing channel located at the second end and traversing the cylindrical body, the dispensing channel adapted to be separately aligned with the actuator channels, wherein the actuator is adapted to receive in a seal-tight manner a plunger that operates to confine an effective chamber defined by the plunger and the second end by moving toward the second end or to expand the effective chamber by moving toward the first end. Preferably, one or more of the chambers are formed within the substrate.

Automated sample processor

Provided is a method of fabricating a solid support with two or more separated regions of a first solid layer of a non-volatile compound deposited thereon, the non-volatile compound required to maintain a chemical proces conducted in a first solution. The method comprises (1) creating an electromagnetic force for attracting charged, solid particles to a surface of the solid support, (2) contacting the surface with the charged particles of non-volatile compound, and depositing the charged particles in an amount effective to provide the non-volatile compound in an amount effective maintain the chemical process.

Method of fabricating a support with dry deposited compounds thereon

Provided is a solid support having dry deposited thereon a first solid layer comprising at least a first compound, the compound for use in a chemical process conducted in a first solution. The invention allows stable forms where the first compound is not stable either (i) for storage in the first solution or (ii) in solution with one or more other compounds of the first layer. Also provided is a tray or kit of wells adapted for conducting a chemical process, each well having a deposited thereon a first solid layer comprising one or more compounds for supporting a chemical process conducted in a first solution, wherein addition of the first liquid to each of the wells dissolves said one or more compounds. Fabrication methods, time-release compositions, and methods of conducting chemical processes are further provided.

Deposited reagents for chemical processes

Provided is a solid support having a composition of at least one compound deposited thereon by electrostatic or controlled field deposition, wherein the compound is attached to the support. Also provided is a method of preparing the solid support by creating an electromagnetic force for attracting particles having a first charge to a surface of the solid support and contacting the surface with the charged particles, which comprise the composition, and thereby coating the surface with the composition. Further provided is a probe array comprising spatially resolved probes deposited and attached on a solid support by electrostatic or controlled field deposition. These methods, supports and arrays provide the building blocks for methods of nucleic acid amplification and for constructing apparatuses for conducting chemical processes.

Solid support with attached molecules

The present invention relates to a method for capturing a class of nucleic acids comprising (a) providing a population of nucleic acids, wherein the population comprises the class; (b) binding a probe moiety to nucleic acids of the class, thereby forming one or more complexes, wherein the probe moiety is attached to a substrate; and (c) capturing the complex. The method can be implemented in certain embodiments in a structure comprised of one or more reservoirs, preferably wherein the reservoirs include one or more second chambers that are in communication with a first chamber. Preferably, the present invention is used to capture the class of nucleic acids that comprise regulatory elements included in a population of nucleic acids isolated from a cell, tissue, or organism. An alternative preferred embodiment of the present invention involves the capture of the class of nucleic acids that comprises certain repetitive elements included in a population of nucleic acids derived from an organism.

Method for capturing a nucleic acid

The nucleic acid amplification reactions of the present invention are conducted isothermally, using non-thermal denaturation procedures, such as occurs in chemical- or electrostatic-based denaturation. Embodiments are set forth for automated forms of the claimed procedures.

Microfluidic method for nucleic acid amplification

In one aspect, the present invention relates to methods of amplifying a target nucleic acid, the methods involving the production of a double-stranded promoter to provide for transcription of the target sequence, and the provision of a poly-A tail in the transcription product. In another aspect, the present invention relates to methods of detecting a target nucleic acid in a sample.

Growing community of inventors

Fair Lawn, NJ, United States of America

Zvi Gerald Loewy