National Institutes of Health, a Component of the US Dept. of Health & Human Services

New York University

Other

Zuzana Biesova

John B Robbins

Rachel Schneerson

Joanna Kubler-Kielb

Jerry Lee Keith

Louis H Miller

Ruth S Nussenzweig

Fathy Majadly

Darrell T Liu

Christopher P Mocca

Disclosed are immunogenic conjugates which elicit an immune response toproteins. In particular examples, theproteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response toin a subject, comprising administering to the subject an immunogenic composition disclosed herein.

Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia

Disclosed are immunogenic conjugates having the general formula:M2e-Cys-S&#x2014;CH&#x2014;C(O)&#x2014;NH&#x2014;CH&#x2014;CH2-C(O&#x2014;)NH-Lys-Pr,were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO&#x2014;NH&#x2014;CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.

Vaccines against influenza virus

Growing community of inventors

Rockville, MD, United States of America

Zuzana Biesova