Chinese Academy of Sciences

China Pharmaceutical University

Zuoquan Xie

Jian Ding

Meiyu Geng

Yan Zhang

Xiyuan Wang

Xiaojun Yang

Ao Zhang

Wenhu Duan

Ancheng Shen

Jinpei Zhou

Yifei Yang

Huibin Zhang

Zhaoxue Hu

Chunyong Ding

Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.

Substituted pyrazolecarboxamides as sting activators

A fluorine-containing substituted benzothiophene compound and a pharmaceutical composition and an application thereof are described. The compound has the structure as shown in formula (I), in which the definitions of each group and substituent are as described in the description. A preparation method of the compound and an anti-tumor application thereof are also described.

Fluorine-containing substituted benzothiophene compound, and pharmaceutical composition and application thereof

Growing community of inventors

Shanghai, China

Zuoquan Xie