Plexxikon Inc.

Opna Bio Sa

Opna Immuno-Oncology Sa

Zuojun Guo

Wayne Spevak

Jiazhong Zhang

John Buell

Ying Zhang

Guoxian Wu

Songyuan Shi

Chao Zhang

Phuongly Pham

Aaron Edward Albers

Jack Walleshauser

Hannah Powers

Mark Vander Wal

Jeffrey Yung Wu

Cuong Q Ly

Prabha N Ibrahim

Jack Lin

Hiroaki Inagaki

Yongil Jin

Xinping Han

Jeffrey Wu

Aaron Albers

Disclosed are compounds capable of modulating CD73, of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R, R, R, A, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Compounds and methods for CD73 modulation and indications therefor

Compounds and methods for EP300 or CBP modulation and indications therefor

Disclosed are compounds of Formula (I) and (Ia): 

Compounds and methods for IDO and TDO modulation, and indications therefor

Disclosed are compounds of Formula I(a): 

Disclosed are compounds having a compound of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, compositions thereof, and uses thereof.

Compounds and methods for kinase modulation

Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R, R, R, each R, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Compounds and methods for kinase modulation, and indications therefor

Growing community of inventors

Pasadena, CA, United States of America

Zuojun Guo