23andme, Inc.

Zuoan Yi

Chingwei Vivian Lee

Krista Maureen McCutcheon

Yu Chen

Shouhua Xiao

Germaine Fuh-Kelly

Yao-ming Huang

Louise Scharf

Tina Thai

Samuel Nalle

Augusta Eleanor Broughton

Navneet Singh

Valentine Yeung

The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.

Anti-CD96 antibodies and methods of use thereof

Growing community of inventors

Mountain View, CA, United States of America

Zuoan Yi