Agency for Science, Technology and Research

Zujun Hou

Yue Wang

Su Huang

A method for dynamic contrast enhanced (DCE) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from the one or more of the plurality of images; registering the plurality of images wherein the organ's region-of-interest has been segmented; deriving a tracer curve for the organ's region-of-interest in the registered images, the tracer curve indicating a change in concentration of a contrast agent flowing through the organ's region-of-interest over a time period; and kinetic modeling by fitting a kinetic model to the tracer curve to generate one or more maps of tissue physiological parameters associated with the kinetic model.

Automatic region-of-interest segmentation and registration of dynamic contrast-enhanced images of colorectal tumors

A method of correcting magnetic resonance images is provided. Seed points having a same expected true intensity are selected from the image points in an image. An intensity correction function I(X) is determined by fitting measured intensities I(X) of the seed points to I(X)=I(X), where x denotes the coordinate of the image points. I(X) is a polynomial function and the values of its coefficients are determined by the fitting. Corrected intensities I(X) for corrected image points are calculated according to I(X)=I(X)/I(X). A corrected image includes the corrected image points.

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Singapore, Singapore

Zujun Hou