Basf Aktiengesellschaft

Ivax Drug Research Institute

Basf Se Corporation

Zsuzsanna Tamara Nagy

Arno Lange

Hans Peter Rath

Helmut Mach

Ulrich Karl

Bela Ivan

János Salát

Ildikó Horváth

Sándor Boros

György Somogyi

István Barta

Júlia Mózes

Gyula Horváth

István Mihály Szabó

Attila Kónya

Éva Ilkóy

Gábor Ambrus

Antónia Jekkel

Viktoria Palfi

Peter Werner Groh

Viktória Palfi

Péter Werner Groh

The present invention relates to a process for preparing carboxyl-terminated polyisobutenes by ozonolysis of polyisobutenes terminated by an ethylenically unsaturated double bond.

Method for producing carboxyl-terminated polyisobutenes

The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6&#x3b2;-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion. The latter comprises the cultivation of astrain which is able to 6&#x3b2;-hydroxylate a compound of general formula (II)&#x2014;wherein R is as defined above&#x2014;at 25-32&#xb0; C. on a nutrient medium containing available carbon&#x2014;and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.

Hydroxylation of compactin pravastatin by micromonospora

Growing community of inventors

Budapest, Hungary

Zsuzsanna Tamara Nagy