Richter Gedeon Vegyeszeti Gyar Rt

Creighton University

Innofinance Altalanos Innovacios Penzintezet

Solvo Biotechnology

Mta Kutatas-Es Szervezetelemzo Intezete

Biosignal Kutato-Fejlesztokft

Zsolt Vadasz

Istvan Teplan

Janos Seprodi

Imre Mezo

Istvan Palyi

Judit Erchegyi

Borbala Vincze

Orsolya Csuka

Judit Horvath

Istvan Schon

Aniko Horvath

Tamas Szirtes

Sandor Lovas

Balazs Szoke

Gabor Makara

Geza Toth

Adrienn Kalnay

Bela Kanyicska

Magdolna Kovacs

Sandor Vigh

Istvan Gyorvari

Gyongyi Bokonyi

Miklos Idei

Peter Peczely

Balas Szoke

Tibor Muray

Agnes Balogh

Gizella Turi

Gyorgy Rappay

Edit Hegedus

Olga N Nee Kuprina

Andras Selmezci

Maria Magocsi

Richard F Murphy

Imre Mezom

Melinda Mora

The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.

GnRH analogues with antitumour effects and pharmaceutical compositions thereof

The invention features novel peptide derivatives called Reversins, and provides for their use in a method of reducing the activity of the multi-drug transporter protein MDR1 in order to overcome multidrug resistance in a mammal. The peptide derivatives are of the formula (I) X,-X,-X,(X,),-X,, wherein n is 0 or 1, and each n is the same or different; X,is BOC, BOC-Asu, Z-Asu, benzyloxycarbonyl, Glu(OBzl)-OBzl, Trp-OMe, Trp-Phe-OMe, Phe-Trp-OMe, Phe-Phe-OtBu, Trp-Trp-OtBu, indoloacetyl, benzoyl, an alkylanine of 1-4 carbons, dibenzylamide, tryptamide, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylamide or dicyclohexylamide; X,is Glu(OBzl), Asp(OBzl), succinyl, O,O-dibenzoyltartaroyl, diphenoyl, muconyl, Thx, Cpa, Asu, Nal, Pen, Phg, Dbt, Lys(BOC), Lys(Z), Cys(Bzl), Thr(Bzl), Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Phe, Tyr(Bzl), or Ser(Bal); X,is Asp, Asu, Lys, Glu, Trp, Thx, Cpa, Nal, Pen, Phg, Dbt, Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Tyr, Phe, or Tyr(Bzl); X,is BOC-Glu(OBzl), Glu(OBzl), Asu, OBzl, Bzl, BOC, BOC-Lys(BOC), Z-Glu(OtBu), Asp(OBzl), Asp(OBz)-OBzl, benzyloxycarbonyl, O-(cyclo-hexyl), fluorenylmethyl ester, Glu(OtBu), Glu(OtBu)-OBzl, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylarnide, or dicyclohexylamide; and X,is OMe, OBzl, OtBu, Phe-OMe, -O-(cyclohexyl), Trp-OMe, (chlorophenyl)-isobutylamide, fluorenylmethyl ester, ONp, 1-aminoadamantane, aminomethylcyclohexane, indoline, phenylethylamide, or dicyclohexylamide.

Compounds for reversing drug resistance

The invention relates to tumor-inhibiting heptapeptide and octapeptide amide derivatives and to a method of treating mammals, including men, suffering from tumors or from the excessive secretion of insulin, glucagon or growth hormone using these compounds.

Tumor growth-inhibiting somatostatin analogues, pharmaceutical

The invention relates to new peptides of the formula ##STR1## wherein R.sup.2 represents Ala or D-Ala,

Analogs of growth hormone releasing factor (GRF) and a method for the

The present invention relates to novel gonadoliberine analogues of formula I

Gonadoliberine analogues of high activity

The invention relates to a process for increasing the sexual activity of birds and useful domestic mammals and for preparing spermatozoa suitable to their propagation. The process of the invention comprises treating sexually mature male birds or useful domestic mammals at least twice and at most four times with 0.1 to 5 .mu.g/kg of body weight of a compound of the general formula (I),

Process for increasing the sexual activity of birds and useful domestic

Growing community of inventors

Budapest, Hungary

Zsolt Vadasz