Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Sorbonne Université

Université Pierre Et Marie Curie

Universite Paris Cité

Inserm (institut National De La Sante Et De La Recherche Medicale)

Paris Sciences Et Lettres-quartier Latin

Université Paris Diderot

Printnet Ltd.

Zsolt Lenkei

Mathieu Pernot

Mickael Tanter

Mickaël Tanter

Jean-Luc Gennisson

Thomas Deffieux

András Málnási Csizmadia

Miklós Képiró

Boglárka Várkuti

The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (), the sample () comprising blood () comprising diffusors and solid tissue (), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.

Method for imaging a sample with blood and associated devices

The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.

Method for obtaining a numerical model associating an objective measurement to a subjective sensation using ultrasound imaging technique and associated device

The present invention relates to highly soluble, non-fluorescent and photostable myosin inhibitors; especially, for in vivo inhibition of the ATPase activity of neuronal non-muscle myosin 2 of formula (II): wherein Q, Q, Q, Q, R, R, Rand Rare as defined in claim. The invention also relates to pharmaceutical compositions or medicaments comprising the compounds of the invention and processes for manufacturing these compounds and their intermediates. 

Water-soluble myosin 2 inhibitors for the treatment of neurological, neuropathic or psychiatric diseases

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Paris, France

Zsolt Lenkei