Bracco Imaging S.p.a.

Zsolt Baranyai

Luciano Lattuada

Alessandro Maiocchi

Roberta Napolitano

Simona Ghiani

Giuseppe Marazzi

Nicole Guidolin

Fulvio Uggeri

Gyula Tircsó

Imre Tóth

Ferenc Krisztián Kálmán

Zoltán Garda

Mauro Botta

László Krusper

Lorenzo Tei

Mariangela Boccalon

Fabio Carniato

Federica Lazzari

Nicol Guidolin

Ivan Hawala

Ferenc Krisztian Kalman

Zoltan Garda

Laszlo Krusper

Gyula Tircso

Imre Toth

Ferenc Krisztián KÁLMÁN

The invention relates to the novel compounds of formula (I) as well as ions, stereoisomers, tautomers, hydrates, solvates, pharmaceutically acceptable salts thereof, or mixtures of the same. The compounds of formula (I) are ligands that are able to chelate Fe(III) ions, thereby generating Fe(III) complexes, which are particularly suitable in diagnostic imaging, for example as contrast agents for magnetic resonance imaging (MRI), due to their high relaxivity, thermodynamic stability, kinetic inertness and redox stability.

1,4-bis-(2-hydroxy-benzyl)-1,4,7-triazacyclononane derivatives and similar compounds as ligands in iron(III) complexes for use as MRI contrast agents

The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising Iand an oxide or a salt of an element of group 11 of the periodic table.

Process for the preparation of 2,4,6-triiodophenol derivatives

The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

Gadolinium bearing PCTA-based contrast agents

A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.

Chelating AAZTA conjugates and complexes thereof

The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.

Ethylenediaminetetraacetic acid bis(amide) derivatives and their respective complexes with Mn(II) ion for use as MRI contrast agent

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Trieste, Italy

Zsolt Baranyai