Pliva Pharmaceutical and Chemical Works

Zrinka Tamburasev

Slobodan Djokic

Gabrijela Kobrehel

Marica Cakara

Gordana Radobolja

Gorjana Radobolja

11-aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof, and process for preparation thereof.

11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well

Novel 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines of the general formula I ##STR1## wherein R stands for C.sub.1 -C.sub.3 -alkyl, halogen or --NHCOR.sup.1, R.sup.1 being C.sub.1 -C.sub.3 -alkyl.

4-Dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines

The new antibiotic compounds N-(4-R-benzenesulfonyl)-erythromycylamine, wherein R is a lower alkyl group having 1-5 carbon atoms, an acylamino group wherein the acyl has 2-4 carbon atoms, or a halo group.

N-(Benzenesulfonyl)-erythromycylamine derivatives

N-(4-R.sup.2 -benzenesulfonyl)-5-O-desosaminyl-erythromycilamine, wherein R.sup.2 is a C.sub.1 -C.sub.5 alkyl radical, halogen or NH.sub.2. The compounds possess antibacterial activity.

Growing community of inventors

Zagreb, Yugoslavia

Zrinka Tamburasev