Pliva, Farmaceutska Industrija, Dionicko Drustvo

Zorica Marusic-Istuk

Gabrijela Kobrehel

Stjepan Mutak

Natasa Marsić

Nedjelko Kujundzić

The invention relates to halo derivatives of 9a-N-(N'-arylcarbamoyl)- and 9a-N-(N&#x2032;-arylthiocarbamoyl)-9-deoxo-9a-aza-9a-homoerythromycin A of the general formula (I)wherein R has the meaning of a substituted aryl group of the formula (II)wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a (C-C)haloalkyl or a (C-C)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen, halo, a (C-C)alkyl or a (C-C)alkoxy group, and X has the meaning of oxygen or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for their preparation, to a process for the preparation of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.

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Samobor, Croatia

Zorica Marusic-Istuk