Nitto-Denko Corporation

Allergan, Inc.

Altea Therapeutics Corporation

Zoran Novakovic

Stuart McRae

Bernadette Messier

Michael R Robinson

James A Burke

Jeremiah P O'Leary

Lon T Spada

Jonathan Eppstein

Mark James Fisher

Stephen Wilson Braun

Loren J Lantz

Regina Spiehl

Wendy E Bowerman

David Mucientes

Michael Strehl

Alazar N Ghebremeskel

Uros Kascak

Rahul Bhagat

David Farquhar

Shawn R Davis

Erin Koch Henkel

Alan Smith

Jonathan A Eppstein

Maximilian Vogl

Vaclav Vojan

Thomas David Reid Ford

Erin Melissa Koch

Jessica Kreher

Ina Michaelis

Richard Mathias

Orilla Werhner

Stuart Mcrae

Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.

Intraocular implant delivery apparatus and methods of use thereof

A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Transdermal porator and patch system and method for using same

A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

Method for transdermal delivery of permeant substances

An assembly for implanting ocular implants into a mammalian eye is provided. The assembly generally includes a cannula having a curved distal end, an injector mechanism coupled to the cannula for linearly moving one or more implant segments in the cannula toward the curved distal end, and a rotator mechanism for rotating the cannula about a longitudinal axis thereof.

Intravitreal applicator

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

An intraocular injector includes a syringe body having open-ended cone disposed in one end thereof along with a piston disposed in the body. A transparent implant holder having a lumen therein is aligned with an open-ended cone, a needle include a proximal end and a distal end with a bevel disposed on the distal end of the needle. A plunger affixed to the piston and slidable within a holder lumen and needle lumen is provided for injecting solid intraocular implants into an eye. A cylindrical syringe body shape facilitates control over the needle bevel orientation during injection of the implant into the eye.

Intraocular injector

Disposable microporation porator

Growing community of inventors

Irvine, CA, United States of America

Zoran Novakovic