Les Laboratoires Servier

Jiangsu Hengrui Medicine Company Ltd.

Qilu Pharmaceutical Co., Ltd.

Institute of Materia Medica

Research Institute of Materia Medica Chinese Acadamy of Medical Sciences

Zongru Guo

Fengming Chu

Guifang Cheng

Ai Ping Bai

Wen Hui Hu

Guangzhong Yang

Pierre Renard

Pierre Lestage

Jingyi Wang

Long Zhang

Jianrong Zhu

Juntian Zhang

Chuanwen Fan

Minghui Zhang

Shousheng Yan

Zhantao Zhang

Qingmin Yang

Zhihong Ren

Zhi Xu

Fang Shen

Shaobo Yang

Xinyi Niu

Bailing Xu

Boling Xu

Haojie Zhou

Dong Lin

Boyan Xu

Ying Li

Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human). 

Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof

The invention relates to sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones compounds having formula (I) wherein Ris selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2-, 3-, or 4-halogen, C&#x2013;C-alkyl, cyclopentyl, cyclohexyl, C&#x2013;C-alkoxy, hydroxy, cyano, nitro, amino or trifluoromethyl;

Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof

The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions containing said compound, and to the medical use thereof in the treatment of diseases relating to the inhibition of cyclooxygenase-2 (COX-2).

Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof

Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them

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Zongru Guo