Changchun Institute of Biological Products, Ministry of Public Health

Zongming Song

Pengfu Wang

Guangpu Li

Baosheng Xie

Shuyan Li

Jing Liu

Wei Wang

Zongju Wan

Xizhen Guangpu Zhang

Jingye Lu

Ben Liang

Lingjiu Liu

Hui Lin

Ying Yu

Ling Zhang

Yong Xue

Jingye Liu

Jing Li

Yuhong Li

The present invention relates to hepatitis A vaccine, especially to a lyophilized attenuated hepatitis A vaccine which can be stored at ambient temperature for extended periods of time, and to a method for producing the same. The present invention further relates to a stabilizer for lyophilized live vaccine and its use in improving thermostability of lyophilized live vaccine during lyophilization processing and storage period after lyophilization.

Freeze-dried hepatitis A attenuated live vaccine and its stabilizer

A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and measles virus or by propagating the two viruses on same diploid cell substrate are disclosed. The combined live vaccine thus prepared is a useful vaccine for preventing the infections with hepatitis A and measles without causing any interference between antigenicity of the two viruses and any serious adverse events due to their mixing or co-culturing.

Combined vaccine against both HAV and measles virus and method of producing it

Growing community of inventors

Changchun, China

Zongming Song